Pleiotropic effects of oxidized phospholipids

Inflammatory profile of oxidized phospholipids.

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammato...

Biophysical Characterization of Oxidized Phospholipids

A great variety of biochemical processes are either confined to or mediated by cellular membranes constructed around a framework provided by a compositionally heterogeneous and highly dynamic bilayer of phospholipid molecules. Accordingly, the physical properties and molecular organization of these mesoscopic supramolecular assemblies are regarded to represent pivotal determinants of the overal...

The role of oxidized phospholipids in atherosclerosis.

There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions. Specific OxPLs have been identified as major regulators of many cell types present in the vessel wall. In endothelial cells, >1,000 genes are regulated. Some of these genes are pro-atherogenic and others anti-atherogenic. The anti...

Oxidized phospholipids: emerging lipid mediators in pathophysiology.

PURPOSE OF REVIEW Oxidized phospholipids are biologically active agents that are generated by lipid peroxidation. They are associated with inflammation, oxidative stress and several diseased states as described by an increasing number of reports. In addition, information about the interaction partners, the binding sites, the intracellular signalling and the metabolizing enzymes of these compoun...

Oxidized Phospholipids: Introduction and Biological Significance